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Journal Article 9

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Berberine alleviates myocardial 1

Fecundity 1

Gut microbiota 1

Hay fever 1

Incubation 1

Intestinal barrier dysfunction 1

Lipin1 1

Lipin3 1

Metabolome 1

Ovulatory dysfunction 1

Predictive capacity 1

Semen analysis 1

albuminuria 1

brachial-ankle pulse wave velocity 1

chronic hepatitis B 1

coagulation dysfunction 1

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Semen Analysis and Fecundity Association Among Women with Polycystic Ovary Syndrome Experiencing OvulatoryDysfunction Treated by Ovulation Induction Article

Jingshu Gao, Yu Wang, Mubai Li, Mengyi Zhu, Xuekui Liu, Xinming Yang, Hongli Ma, Yijuan Cao, Lu Li, Xiaoke Wu

Engineering 2021, Volume 7, Issue 11,   Pages 1586-1591 doi: 10.1016/j.eng.2021.02.012

Abstract: based on a randomized controlled trial investigating infertility among women with PCOS experiencing ovulatoryLogistic regression was used to evaluate the predictive value of semen analysis among ovulatory womenpredictive capacity of semen analysis for treatment outcome in PCOS women with PCOS experiencing with ovulatorydysfunction is limited.

Keywords： Semen analysis     Fecundity     Ovulatory dysfunction     Predictive capacity    

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New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 714-722 doi: 10.1007/s11684-021-0888-8

Abstract: A new definition of metabolic dysfunction-associated fatty liver disease (MAFLD) has recently been proposed

Keywords： metabolic dysfunction-associated fatty liver disease     non-alcoholic fatty liver disease     fibrosis score    

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Endothelial dysfunction in COVID-19 calls for immediate attention: the emerging roles of the endothelium

Weijian Hang, Chen Chen, Xin A. Zhang, Dao Wen Wang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 638-643 doi: 10.1007/s11684-021-0831-z

Abstract: affecting the lungs, COVID-19 can be a severe systemic inflammatory disease that is related to endothelial dysfunctionWe are calling for closer attention to endothelial dysfunction in COVID-19 not only for fully revealing

Keywords： COVID-19     endothelial dysfunction     inflammation reaction     cytokine storm    

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Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

Frontiers of Medicine doi: 10.1007/s11684-023-0983-0

Abstract: Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

Keywords： mitochondrial fission Ca     Berberine alleviates myocardial     murine model HFpEF    

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Prognostic value of fasting glucose on the risk of heart failure and left ventricular systolic dysfunction

Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 70-78 doi: 10.1007/s11684-020-0749-x

Abstract: effect of fasting blood glucose (FBG) on the risk of heart failure (HF) and left ventricular systolic dysfunction

Keywords： myocardial infarction     percutaneous coronary intervention     diabetes mellitus     fasting glucose     heart failure    

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Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center retrospective cohort study

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 111-125 doi: 10.1007/s11684-021-0854-5

Abstract: The coronavirus disease 2019 (COVID-19) has spread globally. Although mixed liver impairment has been reported in COVID-19 patients, the association of liver injury caused by specific subtype especially chronic hepatitis B (CHB) with COVID-19 has not been elucidated. In this multi-center, retrospective, and observational cohort study, 109 CHB and 327 non-CHB patients with COVID-19 were propensity score matched at an approximate ratio of 3:1 on the basis of age, sex, and comorbidities. Demographic characteristics, laboratory examinations, disease severity, and clinical outcomes were compared. Furthermore, univariable and multivariable logistic and Cox regression models were used to explore the risk factors for disease severity and mortality, respectively. A higher proportion of CHB patients (30 of 109 (27.52%)) developed into severe status than non-CHB patients (17 of 327 (5.20%)). In addition to previously reported liver impairment markers, such as alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and total bilirubin, we identified several novel risk factors including elevated lactate dehydrogenase (≥245 U/L, hazard ratio (HR) = 8.639, 95% confidence interval (CI) = 2.528–29.523; P <0.001) and coagulation-related biomarker D-dimer (≥0.5 μg/mL, HR= 4.321, 95% CI= 1.443–12.939; P = 0.009) and decreased albumin (<35 g/L, HR= 0.131, 95% CI= 0.048–0.361; P <0.001) and albumin/globulin ratio (<1.5, HR= 0.123, 95% CI= 0.017–0.918; P = 0.041). In conclusion, COVID-19 patients with CHB were more likely to develop into severe illness and die. The risk factors that we identified may be helpful for early clinical surveillance of critical progression.

Keywords： COVID-19     chronic hepatitis B     liver injury     coagulation dysfunction    

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Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1

Frontiers of Medicine doi: 10.1007/s11684-023-1003-0

Abstract: anabolism, and the decreased Lipin1 in nucleoplasm can reduce PGC1α, further leading to mitochondrial dysfunctionWe also established a relationship between Lipin3 and mitochondrial dysfunction.

Keywords： Lipin3     Lipin1     hypertriglyceridemia     obesity     mitochondrial dysfunction    

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Study on the action of resistin-induced human umbilical vein endothelial cell dysfunction

LI Zhizhen, LI Fangping, YAN Li, LI Feng, LI Yan, CHENG Hua, FU Zuzhi

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 196-199 doi: 10.1007/s11684-007-0037-z

Abstract: Adipokine resistin exerted a direct effect in promoting HUVEC dysfunction by promoting ICAM-1 and ET-

Keywords： endothelial     resistin stimulation     Incubation     pathogenesis     dysfunction    

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Multi-Omics Analysis Provides Insight into the Possible Molecular Mechanism of Hay Fever Based on Gut Microbiota Article

Pei Han, Li-Sha Li, Zi-Xi Wang, Lin Xi, Hang Yu, Lin Cong, Zheng-Wei Zhang, Jie Fu, Ran Peng, Li-Bin Pan, Shu-Rong Ma, Xue-Yan Wang, Hong-Tian Wang, Xiang-Dong Wang, Yan Wang, Jin-Lyu Sun, Jian-Dong Jiang

Engineering 2022, Volume 15, Issue 8,   Pages 115-125 doi: 10.1016/j.eng.2021.03.013

Abstract:

Due to the worldwide epidemic of allergic disease and a cure nowhere in sight, there is a crucial need to explore its pathophysiological mechanisms. As allergic disease has been associated with gut dysbiosis, we searched for a possible mechanism from the perspective of the molecular interface between host and microbiota with concurrent metabolomics and microbiome composition analysis. Sprague-Dawley rats were injected with Artemisia pollen extract to stimulate a hyper reaction to pollen. This hyper reaction decreased the circulation of valine, isoleucine, aspartate, glutamate, glutamine, indole-propionate (IPA), and myo-inositol, and reduced short-chain fatty acids (SCFAs) in feces. Several beneficial genera belonging to Ruminococcaceae, Lachnospiraceae, and Clostridiales declined in the model group, whereas Helicobacter and Akkermansia were only expressed in the model group. Furthermore, the expression of intestinal claudin-3 and liver fatty acid binding protein was downregulated in the model group and associated with metabolic changes and bacteria. Our results suggest that alterations in amino acids as well as their derivatives (especially valine, and IPA which is the reductive product of tryptophan) , SCFAs, and the gut microbiome (specifically Akkermansia and Helicobacter) may disrupt the intestinal barrier function by inhibiting the expression of claudin proteins and affecting the mucus layer, which further results in hay fever.

Keywords： Metabolome     Gut microbiota     Hay fever     Allergic diseases     Intestinal barrier dysfunction    

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Title Author Date Type Operation

Semen Analysis and Fecundity Association Among Women with Polycystic Ovary Syndrome Experiencing OvulatoryDysfunction Treated by Ovulation Induction

Jingshu Gao, Yu Wang, Mubai Li, Mengyi Zhu, Xuekui Liu, Xinming Yang, Hongli Ma, Yijuan Cao, Lu Li, Xiaoke Wu

Journal Article

New definition of metabolic dysfunction-associated fatty liver disease with elevated brachial-ankle pulse

Journal Article

Endothelial dysfunction in COVID-19 calls for immediate attention: the emerging roles of the endothelium

Weijian Hang, Chen Chen, Xin A. Zhang, Dao Wen Wang

Journal Article

Berberine alleviates myocardial diastolic dysfunction by modulating Drp1-mediated mitochondrial fission

Journal Article

Prognostic value of fasting glucose on the risk of heart failure and left ventricular systolic dysfunction

Hui Wang, Yang Zhang, Zhujun Shen, Ligang Fang, Zhenyu Liu, Shuyang Zhang

Journal Article

Clinical characteristics and risk factors of COVID-19 patients with chronic hepatitis B: a multi-center retrospective cohort study

Journal Article

Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and nucleocytoplasmic localization of Lipin1

Journal Article

Study on the action of resistin-induced human umbilical vein endothelial cell dysfunction

LI Zhizhen, LI Fangping, YAN Li, LI Feng, LI Yan, CHENG Hua, FU Zuzhi

Journal Article

Multi-Omics Analysis Provides Insight into the Possible Molecular Mechanism of Hay Fever Based on Gut Microbiota

Pei Han, Li-Sha Li, Zi-Xi Wang, Lin Xi, Hang Yu, Lin Cong, Zheng-Wei Zhang, Jie Fu, Ran Peng, Li-Bin Pan, Shu-Rong Ma, Xue-Yan Wang, Hong-Tian Wang, Xiang-Dong Wang, Yan Wang, Jin-Lyu Sun, Jian-Dong Jiang

Journal Article